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Posts Tagged ‘Thrombophilia’

Thrombophilia – Information Handout for Patients

| Acquired risk factors, Antiphospholipid antibodies, APC resistance, Clots in unusual locations, Deep Vein Thrombosis (DVT), Factor V Leiden, Homocysteine, MTHFR, Inherited, Protein C deficiency, Protein S deficiency, Prothrombin 20210 mutation, Pulmonary Embolism, Thrombophilias, Uncategorized, Venous Clots, Whom to test, Women and blood clots | Comments Off on Thrombophilia – Information Handout for Patients

Stephan Moll, MD writes… An information article on various aspects of thrombophilia, written for patients and family members, was published today – available here – as a Vascular Disease Patient Information Page in the journal Vascular Medicine.  It addresses (a) in which patient with venous thromboembolism to consider thrombophilia  testing, (b) what tests might be appropriate to do, (c) how the test results might influence length of anticoagulation therapy (d), what contraceptives are safe to use in women with a history of DVT or PE or thrombophilia, and (e)  in which family members to consider thrombophilia testing.  This article can be used as an education handout for patients in clinic or the hospital who have DVT, PE, venous thrombosis in unusual locations, or an established thrombophilia.

 

Disclosures:  None

Last updated: April 1st, 2015

Thrombophilia Testing – Reliable on Anticoagulants?

| Acquired risk factors, Antiphospholipid antibodies, APC resistance, Factor V Leiden, Inherited, Protein C deficiency, Protein S deficiency, Prothrombin 20210 mutation, Thrombophilias, Uncategorized | Comments Off on Thrombophilia Testing – Reliable on Anticoagulants?

Stephan Moll, MD writes…  The decision how long to treat a patient with venous thromboembolism (VTE) with anticoagulants can often be made based on the patient’s history alone, i.e. the circumstances of the VTE event (provoked versus unprovoked).  Often, no thrombophilia testing is needed.  However, if one were to do thrombophilia testing, what is the right time to test? Read the rest of this entry »

Ischemic Colitis and Thrombophilia

| Clots in unusual locations, Uncategorized | Comments Off on Ischemic Colitis and Thrombophilia

Stephan Moll, MD writes… 

Ischemic colitis is an uncommon and typically benign disorder.  For mostly unclear reasons, multiple small vessels in the colonic wall have decreased perfusion or become occluded, resulting in patchy, superficially ulcerated areas.  Typically, no surgical intervention is needed and the patient recovers spontaneously within 1-2 weeks.  Often patients have only one episode. Few people have recurrences. Read the rest of this entry »

Pregnancy and Venous Thromboembolism: Prevention, Diagnosis, Treatment

| Uncategorized, Women and blood clots | 1 Comment »

A new guideline about the prevention, diagnosis, and treatment of DVT and PE associated with pregnancy was published today by ACOG (American College of Obstetricians and Gynecologists) in its respected series of Practice Bulletins.  The bulletin includes detailed reference to thromboprophylaxis in pregnant women with thrombophilia. Read the rest of this entry »

Pregnancy Loss and Thrombophilia

| Acquired risk factors, Anticoagulants, Heparin, Inherited, LMWH, Therapy, Thrombophilias, Uncategorized, Whom to test, Women and blood clots | 1 Comment »

How common is pregnancy loss? What are the causes?

Pregnancy loss  in the general population is common. Most losses occur in the first trimester. As many as 5 % of women have 2 or more early losses; 1-2 % have 3 or more early losses [ref 1]. Well established risk factors for pregnancy loss are: (a) advanced maternal age, (b) anatomic uterine abnormalities (fibroids, septum, etc), (c) chromosome abnormalities of fetus, mother or father, (d) comorbid diseases of the mother (endocrine, immunologic).  The acquired antiphospholipid antibody syndrome is also a risk factor for pregnancy loss. The role of inherited thrombophilias contributing to pregnancy loss is less clear. Read the rest of this entry »

Family Member Testing For Thrombophilia

| Factor V Leiden, Inherited, Protein C deficiency, Protein S deficiency, Prothrombin 20210 mutation, Thrombophilias, Uncategorized, Whom to test | Comments Off on Family Member Testing For Thrombophilia

Background

If a thrombophilia (clotting disorder) has been identified in a patient with blood clots (venous thromboembolism = VTE), the question arises whether other family members should be tested for the same thrombophilia.

My Clinical Approach

My approach in clinical practice to thrombophilia testing in family members is summarized in table 1: Family Member Testing. If the patient Read the rest of this entry »

Unexplained Arterial Thrombosis – Causes, Thrombophilia Testing

| Arterial Clots, Uncategorized | Comments Off on Unexplained Arterial Thrombosis – Causes, Thrombophilia Testing

Causes

The 2 main causes of arterial thromboembolism are certainly arteriosclerosis and atrial fibriallation. Only uncommonly do arterial clots occur in persons less than 40 or 50 years of age who do not have arteriosclerosis or atrial fibrillation.  Under these circumstances, a number of uncommon conditions, including  thrombophilias, should be considered and investigated (see table 1: Causes and work-up). Read the rest of this entry »