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Archive for the ‘Inherited’ Category

Thrombophilia – Information Handout for Patients

| Acquired risk factors, Antiphospholipid antibodies, APC resistance, Clots in unusual locations, Deep Vein Thrombosis (DVT), Factor V Leiden, Homocysteine, MTHFR, Inherited, Protein C deficiency, Protein S deficiency, Prothrombin 20210 mutation, Pulmonary Embolism, Thrombophilias, Uncategorized, Venous Clots, Whom to test, Women and blood clots | Comments Off on Thrombophilia – Information Handout for Patients

Stephan Moll, MD writes… An information article on various aspects of thrombophilia, written for patients and family members, was published today – available here – as a Vascular Disease Patient Information Page in the journal Vascular Medicine.  It addresses (a) in which patient with venous thromboembolism to consider thrombophilia  testing, (b) what tests might be appropriate to do, (c) how the test results might influence length of anticoagulation therapy (d), what contraceptives are safe to use in women with a history of DVT or PE or thrombophilia, and (e)  in which family members to consider thrombophilia testing.  This article can be used as an education handout for patients in clinic or the hospital who have DVT, PE, venous thrombosis in unusual locations, or an established thrombophilia.

 

Disclosures:  None

Last updated: April 1st, 2015

International Coagulation Meeting (ISTH 2013): Highlights

| Anticoagulants, Deep Vein Thrombosis (DVT), Eliquis, Inherited, Pradaxa (dabigatran), Pulmonary Embolism, Therapy, Thrombophilias, Uncategorized, Xarelto (Rivaroxaban) | Comments Off on International Coagulation Meeting (ISTH 2013): Highlights

Stephan Moll, MD writes…  A major international coagulation conference, the bi-annual meeting of the International Society for Thrombosis and Haemostasis (ISTH; www.isth.org), took place in Amsterdam, Holland, from June 29th to July 4th, 2013.  The clinically relevant highlights about thrombosis and anticoagulation are summarized below. Read the rest of this entry »

Thrombophilia Testing – Reliable on Anticoagulants?

| Acquired risk factors, Antiphospholipid antibodies, APC resistance, Factor V Leiden, Inherited, Protein C deficiency, Protein S deficiency, Prothrombin 20210 mutation, Thrombophilias, Uncategorized | Comments Off on Thrombophilia Testing – Reliable on Anticoagulants?

Stephan Moll, MD writes…  The decision how long to treat a patient with venous thromboembolism (VTE) with anticoagulants can often be made based on the patient’s history alone, i.e. the circumstances of the VTE event (provoked versus unprovoked).  Often, no thrombophilia testing is needed.  However, if one were to do thrombophilia testing, what is the right time to test? Read the rest of this entry »

Thrombophilia and Insurance

| Inherited, Psychological and social consequences of blood clots, Thrombophilias, Uncategorized | Comments Off on Thrombophilia and Insurance

Liz Varga, Certified Genetic Counselor, Nationwide Children’s Hospital, Columbus OH writes….

Some patients or their family members may be concerned about genetic testing for thrombophilias for fear of genetic discrimination.  Fortunately in the United States, laws are in place that can alleviate this concern.  Read the rest of this entry »

Pregnancy Loss and Thrombophilia

| Acquired risk factors, Anticoagulants, Heparin, Inherited, LMWH, Therapy, Thrombophilias, Uncategorized, Whom to test, Women and blood clots | 1 Comment »

How common is pregnancy loss? What are the causes?

Pregnancy loss  in the general population is common. Most losses occur in the first trimester. As many as 5 % of women have 2 or more early losses; 1-2 % have 3 or more early losses [ref 1]. Well established risk factors for pregnancy loss are: (a) advanced maternal age, (b) anatomic uterine abnormalities (fibroids, septum, etc), (c) chromosome abnormalities of fetus, mother or father, (d) comorbid diseases of the mother (endocrine, immunologic).  The acquired antiphospholipid antibody syndrome is also a risk factor for pregnancy loss. The role of inherited thrombophilias contributing to pregnancy loss is less clear. Read the rest of this entry »

Family Member Testing For Thrombophilia

| Factor V Leiden, Inherited, Protein C deficiency, Protein S deficiency, Prothrombin 20210 mutation, Thrombophilias, Uncategorized, Whom to test | Comments Off on Family Member Testing For Thrombophilia

Background

If a thrombophilia (clotting disorder) has been identified in a patient with blood clots (venous thromboembolism = VTE), the question arises whether other family members should be tested for the same thrombophilia.

My Clinical Approach

My approach in clinical practice to thrombophilia testing in family members is summarized in table 1: Family Member Testing. If the patient Read the rest of this entry »