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Archive for the ‘Women and blood clots’ Category

Contraceptive Use While on Anticoagulants is Safe

| Anticoagulants, Bleeding, Uncategorized, Women and blood clots | Comments Off on Contraceptive Use While on Anticoagulants is Safe

Stephan Moll, MD writes… Interesting and clinically relevant publication this week [ref 1].  It is well known that estrogens and certain progestin preparations increase the risk for venous thromboembolism (VTE).  A woman on an anticoagulant may have heavy menstrual bleeds and hormonal therapy – such as estrogen-progestin contraceptives – may be considered to decrease the bleeding.

The newly published study Read the rest of this entry »

Thrombophilia – Information Handout for Patients

| Acquired risk factors, Antiphospholipid antibodies, APC resistance, Clots in unusual locations, Deep Vein Thrombosis (DVT), Factor V Leiden, Homocysteine, MTHFR, Inherited, Protein C deficiency, Protein S deficiency, Prothrombin 20210 mutation, Pulmonary Embolism, Thrombophilias, Uncategorized, Venous Clots, Whom to test, Women and blood clots | Comments Off on Thrombophilia – Information Handout for Patients

Stephan Moll, MD writes… An information article on various aspects of thrombophilia, written for patients and family members, was published today – available here – as a Vascular Disease Patient Information Page in the journal Vascular Medicine.  It addresses (a) in which patient with venous thromboembolism to consider thrombophilia  testing, (b) what tests might be appropriate to do, (c) how the test results might influence length of anticoagulation therapy (d), what contraceptives are safe to use in women with a history of DVT or PE or thrombophilia, and (e)  in which family members to consider thrombophilia testing.  This article can be used as an education handout for patients in clinic or the hospital who have DVT, PE, venous thrombosis in unusual locations, or an established thrombophilia.

 

Disclosures:  None

Last updated: April 1st, 2015

How Long is the Post-Partum Period in Respect to Thrombosis Risk?

| Uncategorized, Women and blood clots | Comments Off on How Long is the Post-Partum Period in Respect to Thrombosis Risk?

Stephan Moll, MD writes… A recent NEJM study (ref 1) examined whether the risk for thrombosis in women persists beyond the first 6 weeks after delivery.  It found that an increased risk persists for at least 3 months after delivery, although the absolute risk was low after the first 6 weeks.  This is of clinical relevance, as the post-partum period has traditionally often been defined as the 6 weeks after delivery and, if post-partum anticoagulation prophylaxis is considered, it is typically given for 6 weeks only (ACOG – ref 2). Read the rest of this entry »

Yasmin, Yaz and Other Drospirenone Contraceptives: Risk for VTE

| Uncategorized, Women and blood clots | Comments Off on Yasmin, Yaz and Other Drospirenone Contraceptives: Risk for VTE

It has long been known that estrogen-containing birth control preparations (pill, patch, ring) increase the risk for DVT and PE (venous thromboembolism = VTE).  This risk is partially due to the estrogen.  However, part of the risk is also due to the type of progestin in these preparations. Read the rest of this entry »

Pregnancy and Venous Thromboembolism: Prevention, Diagnosis, Treatment

| Uncategorized, Women and blood clots | 1 Comment »

A new guideline about the prevention, diagnosis, and treatment of DVT and PE associated with pregnancy was published today by ACOG (American College of Obstetricians and Gynecologists) in its respected series of Practice Bulletins.  The bulletin includes detailed reference to thromboprophylaxis in pregnant women with thrombophilia. Read the rest of this entry »

Pregnancy Loss and Thrombophilia

| Acquired risk factors, Anticoagulants, Heparin, Inherited, LMWH, Therapy, Thrombophilias, Uncategorized, Whom to test, Women and blood clots | 1 Comment »

How common is pregnancy loss? What are the causes?

Pregnancy loss  in the general population is common. Most losses occur in the first trimester. As many as 5 % of women have 2 or more early losses; 1-2 % have 3 or more early losses [ref 1]. Well established risk factors for pregnancy loss are: (a) advanced maternal age, (b) anatomic uterine abnormalities (fibroids, septum, etc), (c) chromosome abnormalities of fetus, mother or father, (d) comorbid diseases of the mother (endocrine, immunologic).  The acquired antiphospholipid antibody syndrome is also a risk factor for pregnancy loss. The role of inherited thrombophilias contributing to pregnancy loss is less clear. Read the rest of this entry »

Progestin-only Contraceptives and Thrombosis

| Deep Vein Thrombosis (DVT), Pulmonary Embolism, Thrombophilias, Uncategorized, Venous Clots, Women and blood clots | 2 Comments »

Background

It is well known that combination contraceptives (containing estrogens AND progestins) increase the risk for venous thromboembolism (VTE). Relatively few data, however, have been published on progestin-only contraceptives, so that until recently it was not clear whether they increase the risk for venous thromboembolism (VTE) or not. Read the rest of this entry »