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Top 10 Publications on Thrombosis and Anticoagulation from 2012

| Arterial Clots, Aspirin, Plavix, Aggrenox, Tiklid, Persantine, Deep Vein Thrombosis (DVT), Eliquis, Other topics, Pradaxa (dabigatran), Pulmonary Embolism, Uncategorized, Venous Clots, Warfarin (Coumadin), Xarelto (Rivaroxaban) | Comments Off on Top 10 Publications on Thrombosis and Anticoagulation from 2012

Stephan Moll writes…

2012 has been a year with significant progress in the field of venous thromboembolism and anticoagulation.  The three most noteworthy, clinically relevant developments were probably (a) the publication of the new ACCP (American College of Chest Physician) guidelines on antithrombotic therapy in February 2012; (b)  The FDA-approval of rivaroxaban (Xarelto) in November 2012 for the acute treatment of venous thromboembolism (VTE) and long-term secondary prevention; and (c) The FDA-approval of apixaban (Eliquis) in December 2012 for atrial fibrillation and the prevention of arterial thromboembolism.  Here I have listed and summarized the 10 top publications of 2012  in the field of venous thromboembolism and anticoaguation as I see them – the ones clinically most relevant. 

 

Disclosure: I have consulted for Janssen, Boehringer-Ingelheim and Daiichi.

Last updated: Feb 7th, 2013

 

Testosterone and Thrombosis

| Arterial Clots, Deep Vein Thrombosis (DVT), Pulmonary Embolism, Therapy, Uncategorized | 1 Comment »

Testosterone Replacement Therapy

Replacement therapy with low doses of testosterone does not adversely affect blood coagulation status [ref 1] and does not appear to increase the risk of venous or arterial thrombosis. Thrombosis is not listed as a potential side effect in the commly used drug compendium (Micromedex). Furthermore, the 2006 “Clinical Practice Guideline” from the Endocrine Society also does not list thrombosis as a side effect of testosterone replacement therapy, or a previous history of blood clots as a reason not to give testosterone replacement therapy [ref 2]. However, the Androgel® package insert (prescribing information) lists “blood clots in the legs” as a potential side effect Read the rest of this entry »

Unexplained Arterial Thrombosis – Causes, Thrombophilia Testing

| Arterial Clots, Uncategorized | Comments Off on Unexplained Arterial Thrombosis – Causes, Thrombophilia Testing

Causes

The 2 main causes of arterial thromboembolism are certainly arteriosclerosis and atrial fibriallation. Only uncommonly do arterial clots occur in persons less than 40 or 50 years of age who do not have arteriosclerosis or atrial fibrillation.  Under these circumstances, a number of uncommon conditions, including  thrombophilias, should be considered and investigated (see table 1: Causes and work-up). Read the rest of this entry »