Education Blog for Healthcare Professionals

Skyla – A New IUD, Suitable for Women at Risk for DVT and PE

Dr. Stephan Moll writes… Skyla® is a new IUD (intrauterine device) contraceptive, approved in February 2013 by the FDA.  Skyla® is like a small version of the Mirena® IUD.  It has the following features:

  • It is a small, flexible plastic T-shaped device, measuring 28 x 30 mm (Mirena®: 32 x 32 mm);
  • It contains 13.5 mg of the progestin levonorgestrel (Mirena®: 52 mg); it releases the progestin at an average rate of ca. 6 mcg/ day over three years (Mirena®: ca. 20 mcg per day, progressively decreasing to half that value after five years).
  • It is good for 3 years (Mirena®: 5 years).
  • Given its small size, it is particularly suitable for nulliparous women.

Given that that progestin-releasing IUDs do not increase the risk for venous thromboembolism [ref 1], they are a particularly attractive option in women with a history of thrombosis (DVT, PE, etc) or thombophilia (hypercoagulable states).  Thus, the Skyla® IUD seems like a very good choice as well.  Thrombosis is not listed as a possible adverse outcome associated with Skyla® use.

Further resources

  • Commercial Skyla® website: here
  • Full Skyla® prescribing information: here
  • Clot Connect discussion of progestin-contraceptives: here


  1. van Hylckama-Vlieg A et al. The risk of deep vein thrombosis associated with injectable depot-medtoxyprogesterone acetate contraceptives or a levonorgestrel intrauterine device. Arterioscler Thromb Vasc Biol 2010(Nov);30:2297-2230.


Disclosure:  I have no conflict of interest.

Last updated:  June 3rd, 2013


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